16th AD/PD 2022 International Conference on Alzheimer’s and Parkinson’s Diseases
March 18, 2022
Dr. C. Saura chairs the session ¨Tau Propagation and Cellular Interaction 1¨ during the 16th AD/PD 2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders in Barcelona (Spain). Dr. Saura shows the last results of the lab that indicate that loss of presenilins causes tau phosphorylation and aggregation in mice.
AD/PD 2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders
March 15-20, 2022
Our lab participates at the AD/PD 2022 International Conference on Alzheimer’s and Parkinson’s Diseases disease held in Barcelona from March 15-20. Doctoral student Maria Dolores Capilla presented her research project in a poster presentation.
XIX Meeting Spanish Society Neuroscience
November 3-5, 2021
Our lab has participated at the XIX Congreso Nacional de la Sociedad Española de Neurociencia (SENC) at Lleida (Spain) . Doctoral students Anna del Ser and Maria Dolores Capilla presented their doctoral research projects. Dr. Mar Puigdellívol, associated researcher of our group, presented her project on microglia role in Alzheimer’s disease.
VIII INc-UAB Scientific Conferences
October 5-7, 2021
The annual Scientific Conferences of the Instituto de Neurociencias-UAB were celebrated at Sant Feliu de Guixols (Girona) on October 5-7. Doctoral students Anna del Ser, Maria Dolores Capilla and Angel Deprada presented their research projects. In addition, Dr. Mar Puigdellívol, associated researcher of our group at INc-UAB, presented her project on microglia role in Alzheimer’s disease during a plenary lecture.
New study finds that ¨Loss of Presenilin function enhances tau phosphorylation and aggregation in mice¨
September 30, 2021
Our new study published today in Acta Neuropath Communications reveals a Presenilin-dependent loss of function mechanism leading to tau pathology in neurodegeneration. Doctoral student Carlos Soto-Faguás is the first author of this study that shows that deficiency of Presenilins causing familial Alzheimer’s disease leads to tau pathology in dementia.The study opens new avenues for regulating tau pathology in neurodegeneration. Acta Neuropath Comms.
4200 views of our review in Frontiers in Neuroscience: Tissue clearing and expansion methods for imaging brain pathology in neurodegeneration
August 27, 2021
Our review in Frontiers in Neuroscience ¨Tissue clearing and expansion methods for imaging brain pathology in neurodegeneration: from circuits to synapses and beyond¨ received 4200 views after publication on Oct 5th 2020. The manuscript accumulates 4200 views and 850 downloads. Frontiers in Neuroscience
New study published in Nature Communications: Sex-differences in fear memory via Tac2 and Akt/GSK3β/β-catenin pathways
May 3, 2021
Our new study published today in Nat Communications demonstrates for the first time sex differences in the neuronal and molecular processes underlying fear memory in mice. This study was in collaboration with Drs. Raül Andero’s, R. Nadal’s and O.J. Pozo’s groups. Nature Communications
Saura lab launches a new topic in Frontiers in Molecular Neuroscience: Bidirectional communication between synapses and nucleus in brain physiology and pathology
Submission deadline: September 30, 2021
The new topic in Frontiers in Molecular Neuroscience/Frontiers in Synaptic Neuroscience is edited by Drs. A. Parra-Damas, C.A. Saura, B.A. Jordan (Albert Einstein College of Medicine, NY) and TH Ch´ng (Nanyang Technological University Singapore). Frontiers in Molecular Neuroscience
Published two new studies on glutamatergic transmission in neurons and microglia in eNeuro and Cells
March 23, 2020
The first collaborative study with the labs of Drs. J. Rodríguez and A. Miñano (Universitat Autónoma de Barcelona), is featured in the last Issue of eNeuro and it shows a new mechanism of glutamate AMPAR degradation in neurons. The study published in Cells in collaboration with R. Franco and G. Navarro (Universitat de Barcelona) reveals a crosstalk between Adenosine A2AR and NMDAR in microglia. Read more. Link to the papers: eNeuro and Cells
Published new study in eLife showing that Presenilin-1 regulates axon growth in neurons during development
October 15, 2019
The main familial Alzheimer’s disease-linked gene Presenilin-1 regulates axon growth through EphA3/myosyn IIA signaling. Doctoral student Miriam Javier is the first author of this study that revelas a new mechanism by which the Alzheimer’s disease-linked gene Presenilin-1 maintains neuronal morphology during development. This new study published in eLife suggests for the first time a new molecular mechanism linking neurodegeneration and cancer. Read more
VII Scientific Meeting Instituto de Neurociencias UAB
October 1-3, 2019
Dr. Carlos Saura (top) and Maria Dolores Capilla (bottom), doctoral student at Saura lab, participate as speakers at the VII Jornadas Científicas del INc-UAB in Sant Feliu de Guixols (Girona).
Prof. Jesús Avila visits our lab at the INc-UAB
September 27, 2019
Professor Jesús Avila from Centro de Biología Molecular Severo Ochoa (CBM) visits our laboratory at the INc-UAB. Prof. Avila’s talk entitled ¨The role of tau in neurodegeneration¨ opens the new academic year of the Master in Neurosciences-Universitat Autònoma de Barcelona. Picture: C.Saura, J.Avila and M.Coll.
VII International Congress on Research and Innovation in Neurodegenerative Diseases. Fundación CiiieN-Ciberned
September 17-20, 2019
Saura’s lab participates at the VII CiiieN International Congress on Research and Innovation in Neurodegenerative Diseases organized by Fundación Ciiien-Ciberned network in Valencia. Left bottom picture: J. Palop and C. Saura. Right bottom picture: M. Pallàs, J.Alberch, S. Ginés, C.Saura and E. Pérez.
Laura Rubió presents her recent results on CRTC function at the 18th Meeting of the Sociedad Española de Neurociencia
September 5, 2019
Laura Rubió, doctoral student in the lab, presents her new findings in the differential role of CRTC1 and CRTC2 in neurons and astrocytes at the 18th National Meeting of Sociedad Española de Neurociencia (SENC).
18th National Meeting of Sociedad Española de Neurociencia
September 4-6, 2019
Dr. Carlos Saura co-organizes the 18th Congreso Nacional de la Sociedad Española de Neurociencia (SENC) held in Santiago de Compostela from 4 to 6 September. 650 national and international neuroscientists participate in the meeting. Pictures: C. Saura, G. Perea, J. Valero…
18th National Meeting Sociedad Española de Neurociencia
September 4-6, 2019
Dr. Carlos Saura, member of the Junta directiva de la Sociedad Española de Neurociencia, coorganizes the 18th National Meeting of the Sociedad Española de Neurociencia (SENC) held in Santiago de Compostela from 4-6 September. 650 national and international neuroscientists have participated in this important meeting. Plenary lectures by Prof. B.Roska, P.Arlotta and JM Garcia-Segura.
New molecular signature in blood as biomarker for detecting early Alzheimer’s disease
May 17, 2019
The new findings published in Alzheimer’s Research and Therapy reveal a new molecular signature of miRNAs in blood present at early stages of Alzheimer. This study was performed in collaboration with labs of Drs. José Rodríguez (INc-UAB), A. Lleó (Hospital de Sant Pau) and Mercè Boada (Fundación ACE).Photo: Agencia EFE. Read more.
Miriam Javier doctoral thesis defense
February 15, 2019
Doctoral student Miriam Javier defended her doctoral thesis entitled ¨Role of PS/g-secretase-mediated signaling during neuronal development and degeneration¨. Picture (from left to right): Thesis supervisor Dr. C. Saura, Prof. José Rodríguez, Miriam Javier, Javier Sáez Valero and Joaquim Egea.
Prof. María Llorens visits our lab at the Institut de Neurociències-UAB
January 11, 2019
Dr. María Llorens, researcher at the Centro de Biología Molecular Severo Ochoa (CBM-UAM, Madrid), visits our lab at the Institut de Neurociències. Prof. Llorens presents her latest results on ¨Adult neurogenesis in Alzheimer’s disease¨ in the institut Seminar series. Picture: Saura’s lab members and María Llorens (fourth from left).
Prof. Bryen Jordan visits our lab at the Institut de Neurociències-UAB
November 29, 2018
Dr. Bryen Jordan, Albert Einstein College of Medicine (New York, USA) visits our lab at the Institut de Neurociències-UAB. Prof. Jordan is an international recognized scientist in the field of synapse-to-nucleus signaling.Picture: Saura’s lab members and Bryen Jordan (third from right).
XI Simposi de Neurobiologia ¨Future technical advances¨, Societat Catalana de Biologia
November 12-13, 2018
The XI Neurobiology symposium ¨ Future technical advances¨, a biennal meeting organized by Secció Neurobiologia Experimental of the Societat Catalana de Biologia, was held at the Institut d’Estudis Catalans. The meeting was co-organized by Carles Saura and included 50 oral and 65 poster presentations and three international plenary lectures.
Picture (left to right): Josep Saura, Andrea Volterra, Carles Saura and Joaquim Egea
XI Simposi de Neurobiologia ¨Future Technical advances¨, Societat Catalana de Biologia
November 12-13, 2018
200 neuroscientists participated in the biennal XI Neurobiology symposium¨Future technical advances¨of the Societat Catalana de Biologia, Institut d’Estudis Catalans. The meeting was co-organized by Dr. C. Saura and included 50 oral and 65 poster presentations and the plenary lectures from Prof. Lluís Montoliu (CNB, Madrid), Andrea Volterra (Univ. Laussane, Switzerland) and Jesús Pujol (Hospital del Mar, Barcelona).
Link to the meeting: XI Simposi de Neurobiologia
Arnaldo Parra Damas, finalist Young Investigator Award 2018 Societat Catalana de Biologia
July 11, 2018
Postdoc Arnaldo Parra Damas is one of the finalist of the 2018 Young Investigator Award of the Societat Catalana de Biologia. The ceremony of the 3rd Biology night was held at the historical Auditorium of the Universitat de Barcelona.
Cover of journal Biological Psychiatry
May 1, 2018
Scientific image from Saura’s lab in the cover of this month Biological Psychiatry journal. The supplement issue of the 73rd Annual Scientific Meeting of Society of Biological Psychiatry.
Selenium supplementation ameliorates neuropsychiatric and memory symptoms in Alzheimer’s disease mouse model
April 24, 2018
Our new study shows that diet supplementation with selenium, an element highly abundant in nuts, shellfish, fish and pork, reverses anxiety and memory deficits in old 3xTg-AD mice. Selenium decreases aggregated tau pathology but not amyloid plaques. This study, in collaboration with Drs. A. Van der Jeud and R. D’Hooge (Katholieke Universiteit Leuven), is published in the last issue of Scientific Reports 8:6431.
Saura´s lab new study featured in the cover of Small
November 6, 2017
The new study shows the generation and biological application of silicon microphotodiodes as electrical stimulators in neurons. Featured in the inside cover of Small, this study is a collaborative project with Dr. J. Esteve´s lab at the Instituto de Microelectrónica de Barcelona IMB-CNM (CSIC).
XL Congress of SEBBM/FEBS3
Barcelona. October 23-26, 2017
Talk of Dr. C. Saura at the XL Congress of the Sociedad Española de Bioquímica y Biología Molecular (SEEBM). Dr. Saura presents recent results from the lab about the role of the transcriptional coactivator CRTC1 in Alzheimer´s disease at the Molecular Neurobiology Symposium of the XL anual SEBBM Meeting.
17th Meeting Sociedad Española de Neurociencia
Alicante, Spain. September 27-30, 2017
Doctoral student Carlos Soto presents his results on role of Presenilins on tau pathology at the 17th Congress of the Sociedad Española de Neurociencia (SENC) in Alicante (Spain). Dr. C. Saura is part of the Organizing Committee of this biennial meeting of SENC, in which 650 neuroscientists have participated.
Alzheimer´s Global Submit
Lisbon. September 20-22, 2017
Scientific projects from Saura´s lab presented at the Alzheimer´s Global Submit in Lisbon. Doctoral student Miriam Javier shows her recent results on Nrg1 signaling in neurodegeneration mouse models.
Professor Sergi Ferré at INc-UAB
Bellaterra. June 23, 2017
Dr. Sergi Ferré, Chief of the Integrative Neurobiology Section at National Institute of Drug Abuse (Baltimore, USA), shows results on G protein-coupled receptor hereromerization at the INc-UAB seminar series. Picture: S. Ferré (right) and C. Saura (left).
C.Saura´s talk at the BARCCSYN Conference
Barcelona. June 16, 2017
Dr. Carles Saura´s talk on ¨Mapping memory neural circuits with the CREB transcriptional coactivator-1¨ at the Barcelona Computational, Cognitive and Systems Neuroscience (BARCSSYN) Conference.
Miriam Javier: Best Oral Presentation Award.
XIV Scientific Symposium del Dept Bioquimica i Biologia Molecular
Bellaterra. June 6, 2017
Doctoral students Miriam Javier and Carlos Soto participate at the XIV Scientific Symposium del Dept. Bioquímica i Biología Molecular at UAB. Miriam Javier is awarded with the best oral presentation.
Visit to the Instituto Cajal
Madrid. February 17, 2017
Dr. Carles Saura is the invited speaker of the weekly scientific conference at the I. Cajal (Madrid) with a talk entitled ¨Transcriptional mechanisms of memory loss in Alzheimer´s disease¨. Picture: J.L. Trejo and C.A.Saura
Saura´s lab new discoveries on the News
January 18, 2017
Potential treatment for memory loss activating a protein dysregulated in dementia. Several press media highlight the importance of the last discoveries from the lab. Read more.
New mechanism underlying associative memory altered in dementia
January 15, 2017
Our new study published in the cover of Biological Psychiatry demonstrates that CRTC1 regulates associative memory pointing that targeting CRTC1 may hold therapeutic promise in dementia patients.
X Simposi de Neurobiologia 2016
Barcelona. October 6-7, 2016
Saura´s lab members present their latest results at the Catalan Neuroscience meeting organized by C. Saura at the Societal Catalana de Biologia.
X Simposi de Neurobiologia 2016
Barcelona. October 6-7, 2016
Top picture: Dr. Silvia Ginés, Javier DeFelipe and Carles Saura. Bottom: C. Saura, C. Barcia, S. Ginés, C. Malagelada.
X Simposi de Neurobiologia 2016
Barcelona. October 6-7, 2016
The X Neurobiology Symposium, co-organized by Dr. C. Saura, coordinator of Secció de Neurobiologia Experimental de la Societat Catalana de Biologia, was held at the Institut d’Estudis Catalans (Barcelona). The meeting included 84 posters and 53 oral presentations from 240 participants, plus four keynote speakers: R. Klein, M.Schwartz, J. DeFelipe and I. Ferrer. Lilian Enríquez, Miriam Javier and Oihane Ussía presented their latest results.
Info meeting: X Simposi de Neurobiologia
IV International Congress on Research and Innovation in Neurodegenerative Diseases
Alicante. September 24, 2016
Dr. L. Enríquez presents her results on the role of CRTC1 in synapse plasticity and memory at the annual meeting CIIEN and CIBERNED in Alicante (Spain).
New study reveals the pathogenic mechanism caused by a PS1 mutation in an Alzheimer´s disease family
August 22, 2016
This new study from Saura´s lab in collaboration with IIBB-CSIC and Hospital Clinic labs published online in Neurobiology of Aging reveals that a pathogenic mutation in the PSEN-1 gene causes a milder clinical phenotype in familial Alzheimer´s disease.
Miriam Javier presents her latest results at the 10th FENS Forum of Neuroscience
Copenhagen, Denmark. July 5, 2016
Doctoral student Miriam Javier presents her results on the role of presenilin/g-secretase on axon elongation in the developing brain at the 10th FENS (Federation of European Neuroscience Societies) Forum in Copenhagen, Denmark.
Writer Antonio Muñoz Molina visits our lab at the Institut de Neurociències-UAB
Barcelona. June 9, 2016
The internationally recognized Spanish writer Antonio Muñoz Molina visited yesterday our lab and discussed current research projects during his visit at the Institut de Neurociències-UAB.
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México
México DF, México. April 8, 2016
Invited speaker Dr. C.A. Saura at the Instituto de Fisiología Celular of the UNAM. Talk: ¨Transcriptional mechanisms underlying memory loss in Alzheimer´s disease¨.
1st Neurobiology Meeting, Sociedad Mexicana de Bioquímica.Puebla (México)
Puebla, México. April 2-6, 2016
Dr. C.A. Saura presents the results of the lab at the Closing Lecture entitled ¨Mechanisms of memory loss and neurodegeneration in Alzheimer´s disease¨ at the 1st Neurobiology Meeting of the Mexican Society of Biochemistry.
Doctoral thesis defense
February 5, 2016
Title: ¨Role of the transcriptional coactivator CRTC1 on hippocampal-dependent memory in Alzheimer´s disease mouse models¨ by Arnaldo J. Parra. Picture. From left to right: Dr. J-R Cardinaux, Dr. A. Rodriguez-Moreno, Arnaldo J. Parra, Dr. C. Saura and Dr. L. Giménez-Llort
Our Front. Cell. Neurosci. article highly viewed !!!
February 5, 2016
Our last Front. Cell. Neuroscience article entitled: Gene expression parallels synaptic excitability and plasticity changes in Alzheimer´s dieases has received 1,222 views (914 views, 308 do