Dr. Carles Saura and his PhD student Carlos M. Soto have attended 17th Meeting of the Spanish Society of Neuroscience (SENC), which took place in Alicante.

The congress started with the presidential lecture of Dra. Carmen Sandi titled “Who wins and who loses” about how stress and anxiety affect social competitiveness. In this session, they highlight mitochondrial function as a therapeutic target for anxiety-related social dysfunction. In addition, during the first symposium called “Gene Expression in Learning and Memory” it was highlight the role of CRTC1 in long term but not in short term memory and that the chromatin accessibility is necessary for a correct gen regulation as well as the epigenomic modifications like acetylation.

In the symposium of second day “Molecular basis of adult neurogenesis: from epigenetic, to transcriptional and metabolic control”, it was emphasize that the ventricle line has neural stem cell (NSC) outside of the classical neurogenic niche and there are different types of NSC with different plasticity and proliferation, and that proportion of which, change with age. During the plenary lecture of Dr. Tom Mrsic-Flogel “Principles of local and long-range connectivity in the neocortex” he discussed that local connectivity is constrained by response similarity and that most neurons innervate multiple intracortical targets to coordinate activity across the subsets of cortical areas.

The 29th Carlos M. Soto presented a scientific poster titled “Loss of presenilin function results in age-dependent tau phosphorylation” about how the inactivation of presenilins in PScDKO, an AD mouse model, causes an increase in phosphorylated tau levels.

Carlos M. Soto during the poster's session

Carlos M. Soto during the poster’s session

The last day took place the “Neural cell fate determinants during cortical development in health and disease” symposium where it was remarked that CBP is necessary for neuronal growth and synaptic maturation and that DNA binding proteins like CUX1 are important for the establishment of connections between both hemispheres trough corpus callosum. Finally, it was the closing lecture of Dr. Isabel Pérez Otaño about GluN3 subunit of NMDA receptors and its role in preventing premature or disordered synapse stabilization and maturation and in targeting non-used synapses for pruning.