Lopez-Font I., Sogorb-Esteve A., Javier-Torrent M., Brinkmalm G., Herrando-Grabulosa M., García-Lareu B., Turon-Sans J., Rojas-García R., Lleó A., Saura CA., Zetterberg H., Blennow K., Bosch A., Navarro X., Sáez-Valero J. Decreased circulating ErbB4 ectodomains fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis. 
Neurobiol Disease. 2019, 124:428-438. doi: 10.1016/j.nbd.2018.12.021

Franco R., Aguinaga D., Reyes I., Canela EI., Lillo J., Tarutani A., Hasegawa M., Del Ser-Badia A., del Rio J.A, Kreutz M.R., Saura C.A., Navarro G. N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, Tau and phospho-Tau in non-transgenic and transgenic APPSw,Ind mice.
Front Mol Neurosci. 2018, 11:273. doi: 10.3389/fnmol.2018.00273.

Van der Jeugd A., Parra-Damas A., Baeta-Corral R., Soto-Faguás CM., Ahmed T., LaFerla FM., Giménez Llort L., D’Hooge R., Saura C.A. Reversal of memory and neuropsychiatric-like symptoms and reduced tau pathology by selenium treatment in 3xTg-AD mice.
Sci Reports. 2018, 8:6431. doi:10.1038/s41598-018-24741-0

Servián-Morilla E., Robles-Lanuza E., Sanchez-Hidalgo AC., Camacho-García RJ., Paez-Gómez JA., Mavillard F., Saura C.A, Martinez-Mir A. and Scholl FG. Proteolytic processing of neurexins by presenilins sustains synaptic vesicle release.
J. Neurosci. 38(4): 901-917. DOI: 10.1523/JNEUROSCI.1357-17.2017

Navarro G., Borroto-Escuela D., Angelats E., Etayo I., Reyes-Resina I., Pulido-Salgado M., Rodriguez-Perez A., Canela E.I., Saura J., Lanciego JL., Labandeira-Garcia JL., Saura C.A., Fuxe K., Franco R. Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia.Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levo-dopa-induced dyskinesia.
Brain, Behavior and Immun. 2018, 67: 137-151. doi:10.1016/j.bbi.2017.08.015

Parra-Damas A., Rubió-Ferrarons L, Shen J. and Saura C.A.  CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters
Sci Reports. 2017, 7(1):18004. doi: 10.1038/s41598-017-18215-y.

Vargas-Estevez,C., Duch, M, Duque, M. del Campo F.J., Enríquez-Barreto, L., Murillo G.,Torras N., Plaza J.A. Saura C..A.*, Esteve,J.* Suspended silicon micro-photodiodes for electrochemical and biological applications.
Small. 2017, 13(41). doi:10.1002/smll.201701920. doi:10.1002/smll.201701920

Parra-Damas A., Chen M., Enríquez-Barreto L., Ortega L., Acosta S., Camats Perna J., Fullana N., Aguilera J., Rodríguez-Alvarez J., and Saura C.A.  CRTC1 function during memory encoding is disrupted in neurodegeneration. 
Biological Psychiatry. 2017, 81(2):111-123doi:10.1016/j.biopsych.2016.06.025

Sarroca S., Molina-Martínez P., Aresté C., Etzrodt M., García de Frutos P., Gasa R., Antonell A., Molinuevo JL, Sánchez-Valle R., Saura C.A., Lladó A., Sanfeliu C. Preservation of cell survival mechanisms by the presenilin-1 K239N mutation may cause its milder clinical phenotype.
Neurobiology of Aging 2016, 46: 169-179.doi:10.1016/j.neurobiolaging.2016.07.002

Parra-Damas A., Valero J., Chen M., España J., Martin E., Ferrer I., Rodríguez-Alvarez J. and Saura C.A.  Crtc1 activates a transcriptional program deregulated at early Alzheimer’s disease-related stages
J Neurosci. 2014, 34(17):5776-87. Featured cover.  doi: 10.1523/JNEUROSCI.5288-13.2014

Xifró X., Miñano-Molina A.J., Saura C.A., Rodríguez-Álvarez J. Ras protein activation is a key event in activity-dependent  survival of cerebellar granule neurons.
J Biol Chem. 2014, 289(12):8462-72. doi: 10.1074/jbc.M113.536375

Balmaceda V., Cuchillo-Ibañez, I., Pujadas, L., Garcia-Ayllón, M-S., Saura C.A., Nimpf, J., Soriano, E. and Sáez-Valero J. ApoER2 processing by presenilin-1 modulates reelin expression.
FASEB J.  2014, 28(4):1543-54   doi: 10.1096/fj.13-239350

Carriba P., Pardo L., Parra-Damas A., Lichtenstein M.P. Saura C.A., Pujol A., Masgrau R and Galea E. ATP and noradrenaline activate CREB in astrocytes via non canonical Ca2+ and cAMP independent pathways.
GLIA. 2012,60(9):1330-1344. doi: 10.1002/glia.22352

Garcia-Ayllón M-S., Campanari M-L., Brinkmalm G., Rábano A., Alom J., Saura C.A., Andreasen N., Blenow K. and Sáez-Valero J. CSF Presenilin-1 complexes are increased in Alzheimer’s disease.
Acta Neuropathol Comm. 2013, 1:46. doi: 10.1186/2051-5960-1-46

Fadó R., Moubarak R.S., Miñano-Molina, A. J., Barneda-Zahonero B., Valero J., Saura C.A., Moran J., Comella J.C. and Rodríguez-Álvarez J. X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.
Sci Rep. 2013, 3:2397. doi: 10.1038/srep02397

Giralt A., Puigdellivol M., Paoletti P., Carretón O., Valero J., Parra-Damas A., Saura C.A, Alberch J., and Ginés S. Long-term memory deficits in Huntington’s disease are associated with reduced CBP histone acetylase activity.
Hum Mol Genet. 2012, 21(6):1203-16.  doi: 10.1093/hmg/ddr552

Barneda-Zahonero B., Servitja J.M., Badiola N., Minano-Molina A.J., Fado R., Saura C.A., Rodriguez-Alvarez J. Nurr1 is required for NMDA receptor-mediated neuronal survival.
J Biol Chem. 2012, 287(14):11351-62 doi: 10.1074/jbc.M111.272427

Miñano-Molina A.J., España J., Martin E., Barneda-Zahonero B., Fadó R., Solé M., Trullás R., Saura C.A. and Rodríguez-Alvarez J. Soluble oligomers of amyloid-β peptides disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributing to early synapse dysfunction.
J Biol Chem.  2011, 286(31):27311-27321.  doi: 10.1074/jbc.M111.227504

Saura C.A., Servián E. and Gómez-Scholl F. Presenilin/γ-secretase regulates neurexin processing at synapses.
PloS One. 2011, 6(4) e19430.  doi: 10.1371/journal.pone.0019430

Valero J., España J., Parra-Damas A., Martin E., Rodríguez-Alvarez J. and Saura C.A. Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APPSw,Ind transgenic mice.
PloS One. 2011, 6(2) e16832. doi: 10.1371/journal.pone.0016832

España J., Valero J., Miñano A., Masgrau R., Martin E., Guardia-Laguarta C., Lleó A., Giménez-Llort L., Rodríguez-Alvarez J. and Saura C.A. β-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1.
J Neurosci. 2010, 30(28):9402-10.  doi: 10.1523/JNEUROSCI.2154-10.2010

España J., Giménez-Llort L., Valero Gómez-Lobo J., Miñano A., Rábano A., Rodríguez-Alvarez J., LaFerla F.M. and Saura C.A.Intraneuronal Aβaccumulation in the amygdala enhances fear and anxiety in Alzheimer’s disease transgenic mice.
Biol Psychiatry. 2010, 67(6):513-521.  doi: 10.1016/j.biopsych.2009.06.015

Coma M., Serenó L., Da Rocha-Souto B., Scotton T.C., España, J., Sánchez M.B., Rodríguez M., Guardia-Laguarta C., Garcia-Alloza M., Borrelli L.A., Clarimón J., Lleó A., Bacskai B.J., Saura C.A., Hyman B.T., Gómez-Isla T.  Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer’s disease.
Neurobiol Disease 2010, 38(3):482-491  doi: 10.1016/j.nbd.2010.01.019

Rocher-Ros V., Marco S., Mao J.H., Gines, S., Metzger D., Chambon, P., Balmain A. and Saura C.A.Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.
Oncogene. 2010, 29(20):2950-61.  doi: 10.1038/onc.2010.57

Barneda-Zahonero B., Miñano A., Badiola N., Fadó R., Xifró X., Saura C.A. and Rodriguez-Alvarez J. BMP-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway.
Mol Biol Cell. 2009, 20(24):5051-63  doi: 10.1091/mbc.E09-05-0424

Miñano A., Pérez V., Xifró X., Barneda-Zahonero B., Saura C.A. and Rodriguez-Alvarez J. Estradiol facilitates neurite maintenance by a Src/Ras/ERK signalling pathway.
Mol Cell Neurosci
. 2008, 39(2):143-51  doi: 10.1016/j.mcn.2008.06.001

Saura C.A., Chen G., Malkani S., Choi S.-Y., Zhang D., Takahashi R.H., Gouras G.K., Kirkwood A., Morris R.G.M. and Shen J. Conditional inactivation of presenilin-1 prevents amyloid accumulation and temporarily rescues associative and working memory impairments in APP transgenic mice.
J Neurosci.
2005, 25(29):6755-64.

Cervantes S, Saura C.A., Pomares E., Gonzalez-Duarte R. and Marfany G.
Functional implications of the presenilin dimerization: Reconstitution of γ-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.

J Biol Chem.
2004, 279(35):36519-36529.

Beglopoulos V., Sun X., Saura C.A., Lemere C. A., Kim R. D. and Shen J.
Reduced β-amyloid production and increased inflammatory responses in presenilin conditional knockout mice.

J Biol Chem
. 2004, 279(45):46907-46914.

Saura C.A., Choi S.-Y., Beglopoulos V., Malkani S., Zhang D., Shankaranarayana Rao B. S., Chattarji S., Kelleher III R. J., Kandel E. R., Duff K., Kirkwood A. and Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Neuron. 2004, 42:23-36.

Gines S., Ivanova E., Seong I-S, Saura C.A and MacDonald M.E. Enhanced Akt signaling is an early pro-survival response that reflects N-Methyl-D-aspartate receptor activation in Huntington’s disease knock-in striatal cells.
J Biol Chem. 2003, 278(50):50514-50522.

Leem J.Y., Saura C.A., Pietrzik C., Christianson J., Wanamaker C, King L.T., Veselits M.L., Tomita T., Gasparini L., Iwatsubo T., Xu H., Green W.N., Koo E.H., and Thinakaran G. A role of presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
Neurobiol Dis. 2002, 11(1):64-82

Saura C.A.*, Yu H.*, Choi S-Y., Sun L.D., Yang X., Handler M., Kawarabayashi T., Younkin L., Fedeles B., Wilson M.A., Younkin S., Kandel E.R., Kirkwood A. and Shen J. APP processing and synaptic plasticity in presenilin-1 conditional mice.
2001, 31(5):713-726.

Saura C.A., Tomita T., Takahashi M., Leem J.Y, Honda T., Iwatsubo T. and Thinakaran G. The non-conserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early-onset Alzheimer’s disease-linked PS variants.
J Biol Chem
.  2000, 275(22):17136-17142.

Saura C.A., Tomita T., Davenport F., Harris C.L, Iwatsubo T. and Thinakaran G. Evidence that intramolecular associations between Presenilin domains are obligatory for endoproteolytic processing.
J Biol Chem
. 1999, 274(20):13818-13823.