The Saura‘s lab at the Universitat Autònoma de Barcelona investigates the cellular and molecular mechanisms involved in the pathogenesis of cognitive disorders, particularly in Alzheimer’s disease.

Our research efforts are currently focused on understanding how brain functions during memory processing and the cellular and molecular mechanisms involved in brain dysfunction, memory loss and neurodegeneration in age-related cognitive disorders. Our lab combines molecular approaches and cutting-edge genomic, transcriptomic and proteomic methodologies to better understand the molecular pathways causing neuronal dysfunction, memory loss and neurodegeneration in Alzheimer’s disease.

Dr. Carles Saura’s lab investigates the transcriptional pathways that regulate synaptic plasticity underlying cognition and memory, which allows a better understanding of the mechanisms mediating gene expression changes causing synaptic dysfunction and memory loss in cognitive disorders, especially in Alzheimer’s disease.

We use pioneering approaches to generate novel transgenic and knockout mouse models of neurodegeneration that are used for testing new therapeutic strategies (pharmacological, gene therapy, cognitive stimulation…) for future treatment of age-related dementia disorders. Our research projects provide knowledge of novel molecular targets and therapeutic strategies for early treatment of Alzheimer’s disease and related neurological disorders.

Our investigations focus in three main topics:

1. Cellular mechanisms in Alzheimer’s  disease.

2. Novel research tools and models of neurodegeneration.

3. Therapies for Alzheimer’s  disease and cognitive disorders.

Lab news…

Researchers at Saura's laboratory

Doctoral Thesis Defense. Miriam Javier presents her doctoral thesis entitled: ¨Role of PS/g-secretase-mediated signaling during neuronal development and degeneration¨. February 15, 2019. Read more

Cover of Biological Psychiatry journal. Artistic image of Saura’s lab featured in the cover of Biological Psychiatry, Suppl: 73rd Annual Scientific Convention and Meeting of Society of Biological Psychiatry. May 1, 2018. Read more

New study demonstrates the benefits of selenium in Alzheimer’s disease. Published in Scientific Reports (Nature Publ Group), this international collaborative study demonstrates that a diet rich in selenium, an element abundant in nuts, sellfish and meat, reverses neuropsychiatric and memory symptoms in Alzheimer’s disease mice at advanced stages. April 24, 2018Read more

The Saura lab is actively exploring and developing research on the following topics: